High Quality 99%Min CAS No 1310726-60-3 Upadacitinib Abt 494 Abt-494 Powder

Product Details
Customization: Available
Powder: Yes
Customized: Non-Customized
Diamond Member Since 2021

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Basic Info.

State
Solid
Purity
>99%
Appearance
White Powder
Grade
Pharmaceutical Grade
MOQ
1g
Sample
Available with Charge
Shelf Life
2 Years
Shipping Way
Express/ by Air / by Sea
CAS No.
1310726-60-3
Mf
C17h19f3n6o
Type
Pharmaceutical Intermediates
Transport Package
Aluminium Foil Bag
Specification
1kg in one bag, 20kgs in one drum
Trademark
Huirui
Origin
China
HS Code
3001909099
Production Capacity
5000kgs/Month

Product Description

Despcription

Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage and bone destruction, leading to co-morbidities. Despite a variety of therapeutic agents available for treatment, up to 40% of the patients do not respond to current therapies, including biological therapies. The etiology of the disease is mostly unknown; however, the role of JAK as a driver of immune-mediated conditions was discovered, leading to the use of JAK as therapeutic targets for rheumatoid arthritis. To reduce dose-related toxicity (as seen with some pan-JAK inhibitors) without significantly affecting efficacy, more selective JAK1 inhibitors, upadacitinib and [filgotinib], were developed. The FDA approved Upadacitinib in August 2019 for the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate. In December 2019, it was additionally approved by the European Commission for the same indication in patients with inadequate response or intolerance to one or more DMARDs and can be used as monotherapy or in combination with methotrexate. It is currently being investigated in several clinical trials assessing its therapeutic effectiveness in other inflammatory diseases, such as psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, and atopic dermatitis.

Application

Upadacitinib is indicated for the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate. For patients who do not responded well or are intolerant to one or more disease-modifying anti-rheumatic drugs (DMARDs), upadacitinib may be used as monotherapy or in combination with methotrexate.

Packing & Delivery
By Express
 
By Air
 
By Sea
 
Suitable for under 20kg
 
Suitable for more than 20kg
 
Suitable for more than 500kg
 
Fast: 5-9 days
 
Fast: 3-7days
 
slow: 7-30 days
 
High cost
 
Medium cost
 
Low cost
 
Door to door service
 
Port to port service
 
Port to port service
 
We cooperate with many freight forwarders, we will choose the most suitable shipping method when shipping goods to different areas.
Exhibition
 
About us

Shanghai HuiRui Chemical Technology Co., Ltd.(HuiChem) is a high-tech enterprise engaged in the area of health care & nutrition. HuiChem have been working closely with our customers we deliver products and solutions that create value and competitive advantage while positively impacting the world we live in, as well as attentive service for the purpose to meet the demand of customers, spare no effort to create value for customers.

HuiChem is now headquartered in Shanghai, and has offices in Jiangsu, Shandong, Anhui and HongKong. Its Shanghai headquarters has nearly 2000 square meters of operation premises, including a total of over 1500 square meters of synthesis laboratories and more than 200 square meters of analysis laboratories (equipped with AAS, LC-MS, FTIR, NMR and other basic test equipment). We have set up two pilot scale laboratories, which lay speedy and stable foundation for process amplification and production of superior products. Besides, we have partner factories that are responsible for the commercial production in Jiangsu Province and Shandong Province. All of those, ensuring growing customer demand and smooth commercial production. We have been certified ISO9001:2008 and ISO14001:2004. The company has established good cooperative relationships with Shanghai Institute of Organic Chemistry of Chinese Academy of Sciences(SIOC), Shanghai Institute of Materia Medica (SIMM), University of Science and Technology of China and Fudan University, and carried out a variety of creative R&D cooperation activities.
Advantages

Service:
1. Any inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.


Advantages:
1. Faster delivery: Sample order in stock and 3-7 days for bulk production.
2. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
3. After-Sale Service: 
1)International Authorized Third-Party Test For The Products You Demand. 
2)60 Days Warranty of quality of goods.


FAQ

Q1. How does your factory control quality?
A:All the raw material purchasing and production quality control are strictly following the ISO9001: 2008 management system. Besides, the full-featured detection equipment and GMP quality management system to provide the strongest guarantee for high quality product. We can provide our customers the detailed test report for the quality evaluation before the sample.

Q2. What's your main markets? 
A:North America, Europe, Asia, etc.

Q3. What is your delivery term and delivery period? 
A:We accept FOB, CIF, etc. You can choose the one which is the most convenient or cost effective for you. The sample within 3 days, and bulk order within 5 days.

Q4. What is your package?
A:Powder: PE bag, glass bottle or PTFE bottle for inner packing, and aluminium foil bag for outer packing.
Liquid: glass bottle or PTFE bottle for inner packing, and aluminium foil bag for outer packing.
Bulk order: Fiber drum or steel drum.

Q5. What is the payment term? 
A:Normally we advise customers use Trade Assurance(is a free payment protection service for buyers is offered by Alibaba group), and we also receive T/T, Western Union or L/C.

Q6. Will you supply samples for test the quality? 
A:We'd like to offer our customers the free samples for the quality evaluation for most products, but the shipping cost is borne by customers.

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