| Customization: | Available |
|---|---|
| CAS No.: | 7150-23-4 |
| Formula: | C7h8n2o2 |
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JBSNF-000088 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50s = 1.8, 2.8, and 5 µM for human, monkey, and mouse NNMT, respectively).1 It inhibits NNMT and reduces 1-methyl-nicotinamide (MNA) levels in U2OS and 3T3L1 cells (IC50s = 1.6 and 6.3 µM, respectively). JBSNF-000088 (50 mg/kg) reduces visceral white adipose tissue (WAT) MNA levels, body weight, fed blood glucose levels, and plasma and liver triglyceride levels, and improves oral glucose tolerance in a mouse model of diet-induced obesity (DIO). It also improves glucose tolerance, without affecting body weight, in the ob/ob and db/db mouse models of insulin resistance and diabetes, respectively.
| Product name | JBSNF-000088 |
| CAS No. | 7150-23-4 |
| Purity | 99% |
| Appearance | White Solid Powder |
| Application | Healthcare |
| Package | Aluminum Bag or Drum |
| Storage | Store in a closed container in a cool and dry place, below 5ºC. |
| Retest Date | 2 years |
Profile
Shanghai HuiRui Chemical Technology Co., Ltd. (HuiChem) is a high-tech enterprise engaged in health care and nutrition. HuiChem works closely with its customers to deliver products and solutions that create value and competitive advantage while positively impacting the world. The company provides attentive service to meet customer demands and spares no effort in creating value for its customers.
HuiChem is headquartered in Shanghai and has offices in Jiangsu, Shandong, Anhui, and Hong Kong. The Shanghai headquarters spans nearly 2000 square meters, including over 1500 square meters of synthesis laboratories and more than 200 square meters of analysis laboratories equipped with AAS, LC-MS, FTIR, NMR, and other basic test equipment. The company has also set up two pilot-scale laboratories to lay a speedy and stable foundation for process amplification and production of superior products. Additionally, HuiChem has partner factories responsible for commercial production in Jiangsu Province and Shandong Province, ensuring smooth output to meet growing customer demand. The company has been certified with ISO9001:2008 and ISO14001:2004.
HuiChem believes that everything originates from innovation and combines the power of science and the passion for innovation. The company is committed to connecting chemistry and innovation with sustainability principles to create a healthy life.
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