| Customization: | Available |
|---|---|
| CAS No.: | 4449-51-8 |
| Formula: | C27h41no2 |
Suppliers with verified business licenses
Audited Supplier Audited by an independent third-party inspection agency
Cyclopamine (11-deoxojervine) is a naturally-occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by suppressing the hedgehog gene (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
Function:
Cyclopamine inhibits the hedgehog signaling pathway (Hh) by influencing the balance between the active and inactive forms of the Smoothened protein.Cyclopamine is currently being investigated as a treatment agent in basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma, tumors that result from excessive Hh activity [2], glioblastoma, and as a treatment agent for multiple myeloma.
| Product name | Cyclopamine |
| CAS No. | 4449-51-8 |
| Purity | 99% |
| Appearance | Powder |
| Application | Healthcare and medicine |
| Package | Aluminum Bag or Drum |
| Storage | Store in a closed container in a cool and dry place, below 5ºC. |
| Retest Date | 2 years |
Profile
Shanghai HuiRui Chemical Technology Co., Ltd. (HuiChem) is a high-tech enterprise engaged in health care and nutrition. HuiChem works closely with its customers to deliver products and solutions that create value and competitive advantage while positively impacting the world. The company provides attentive service to meet customer demands and spares no effort in creating value for its customers.
HuiChem is headquartered in Shanghai and has offices in Jiangsu, Shandong, Anhui, and Hong Kong. The Shanghai headquarters spans nearly 2000 square meters, including over 1500 square meters of synthesis laboratories and more than 200 square meters of analysis laboratories equipped with AAS, LC-MS, FTIR, NMR, and other basic test equipment. The company has also set up two pilot-scale laboratories to lay a speedy and stable foundation for process amplification and production of superior products. Additionally, HuiChem has partner factories responsible for commercial production in Jiangsu Province and Shandong Province, ensuring smooth output to meet growing customer demand. The company has been certified with ISO9001:2008 and ISO14001:2004.
HuiChem believes that everything originates from innovation and combines the power of science and the passion for innovation. The company is committed to connecting chemistry and innovation with sustainability principles to create a healthy life.
){kind=link}