| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Non-Customized |
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Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxid e (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.
| By Express | By Air | By Sea |
| Suitable for under 50kg | Suitable for more than 50kg | Suitable for more than 500kg |
| Fast: 3-7 days | Fast: 3-7 days | Slow: 3-10 days |
| High cost | Medium cost | Medium cost |
| Door to door service | Door to door service | Port to port service |
Shanghai HuiRui Chemical Technology Co., Ltd.(HuiCHem) is a high-tech enterprise engaged in the area of health care & nutrition. HuiChem have been working closely with our customers we deliver products and solutions that create value and competitive advantage while positively impacting the world we live in, as well as attentive service for the purpose to meet the demand of customers, spare no effort to create value for customers.
HuiChem is now headquartered in Shanghai, and has offices in Jiangsu, Shandong, Anhui and HongKong. Its Shanghai headquarters has nearly 2000 square meters of operation premises, including a total of over 1500 square meters of synthesis laboratories and more than 200 square meters of analysis laboratories (equipped with AAS, LC-MS, FTIR, NMR and other basic test equipment). We have set up two pilot scale laboratories, which lay speedy and stable foundation for process amplification and production of superior products. Besides, we have partner factories that are responsible for the commercial production in Jiangsu Province and Shandong Province. All of those, ensuring growing customer demand and smooth commercial production. We have been certified ISO9001:2008 and ISO14001:2004. The company has established good cooperative relationships with Shanghai Institute of Organic Chemistry of Chinese Academy of Sciences(SIOC), Shanghai Institute of Materia Medica (SIMM), University of Science and Technology of China and Fudan University, and carried out a variety of creative R&D cooperation activities.
We attach great importance to technical innovation and follow the latest dynamic of discovery and development to research and develop new products relying on advanced technology of synthetic chemistry, medicinal chemistry, biochemistry and analytical chemistry. We also pay attention to introduce and foster professional and technical personnel, the company has a group of vigorous and well-trained employees, and strong technical R&D forces. HuiChem has established a new system covering research and development, production and sales. Based on advanced equipment and strict management, always pursue the "open, inclusion, innovation, sharing" business philosophy, creating a win-win cooperation platform.
Everything originates from innovation. HuiChem combines the power of science and the passion of innovation. We believe to connect chemistry and innovation with the principles of sustainability to create a healthy life.
1. Faster delivery: Sample order in stock and 3-7 days for bulk production.
2. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
3. After-Sale Service:
1)International Authorized Third-Party Test For The Products You Demand.
2)60 Days Warranty of quality of goods.
Q1. How does your factory control quality?
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